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Association between Urinary Advanced Glycation End Products and Subclinical Inflammation in Children and Adolescents:

Margherita Borriello1,2, Fabio Lauria1, Ivana Sirangelo1,2

  • 1Institute of Food Sciences, National Research Council, Via Roma 64, 83100 Avellino, Italy.

Nutrients
|October 14, 2022
PubMed

Insights

Advanced Glycation End Products (AGEs) are linked to inflammation in children. This study shows urinary AGEs correlate with inflammation biomarkers, suggesting they can indicate subclinical inflammation in youth.

Area of Science:

  • Pediatric Health
  • Biochemistry
  • Inflammation Research

Background:

  • Advanced Glycation End Products (AGEs) are linked to inflammation in adults.
  • Evidence for this association in children is inconsistent.
  • Subclinical inflammation is a growing concern in pediatric populations.

Purpose of the Study:

  • To investigate the association between urinary AGEs and subclinical inflammation biomarkers in healthy children and adolescents.
  • To determine if fluorescent AGEs can serve as a non-invasive marker for inflammation in pediatric populations.
  • To explore correlations between AGEs and specific inflammatory markers like hs-CRP, IL-15, IP-10, and IL-1Ra.

Main Methods:

  • Analysis of urinary AGEs using fluorescence spectroscopy in 676 Italian children/adolescents.
  • Measurement of high-sensitivity C-reactive protein (hs-CRP) as the primary inflammation biomarker.
  • Assessment of secondary inflammation biomarkers including IL-15, IP-10, and IL-1Ra.

Main Results:

  • Children with higher urinary AGEs had significantly elevated hs-CRP levels (p=0.002).
  • Positive correlations were observed between urinary AGEs and hs-CRP (p=0.0001), IL-15 (p=0.001), IP-10 (p=0.006), and IL-1Ra (p=0.001).
  • Urinary AGEs, age, and BMI Z-score independently predicted hs-CRP levels in multiple regression analysis.

Conclusions:

  • Urinary AGEs measurement is a simple, non-invasive method to assess inflammation in children and adolescents.
  • The findings support a role for AGEs as biomarkers of subclinical inflammation in healthy youth.
  • This research highlights the potential of AGEs as early indicators of inflammatory processes in pediatric populations.

Keywords:
CRPI.Family projectadvanced glycation end productsbiomarkerschildreninflammationurinary AGEs

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