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Echocardiographic left ventricular mass and function in the hypertensive baboon.
Hypertension (Dallas, Tex. : 1979)
|September 1, 1987
Summary
M-mode echocardiography accurately estimates left ventricular mass in baboons. Hypertensive baboons show concentric hypertrophy, maintaining cardiac stress despite reduced ventricular function.
Area of Science:
- Cardiovascular Physiology
- Animal Models of Hypertension
- Echocardiography
Background:
- Nonhuman primates with chronic hypertension are valuable models for studying cardiac hypertrophy.
- Noninvasive techniques like echocardiography are crucial for longitudinal studies.
Purpose of the Study:
- To validate M-mode echocardiography for estimating left ventricular mass in baboons.
- To characterize left ventricular size and function in baboons with chronic renal hypertension.
Main Methods:
- M-mode echocardiography was used to measure left ventricular mass and dimensions.
- High-fidelity pressure measurements were employed in normotensive and hypertensive baboons.
- Necropsy weights were used to validate echocardiographic mass estimations.
Main Results:
- Echocardiographically determined left ventricular mass correlated well with necropsy weights (r=0.94).
- Hypertensive baboons exhibited significantly higher left ventricular systolic pressure and mass compared to normotensive controls.
- Concentric hypertrophy in hypertensive baboons maintained left ventricular meridional stress, despite a ~25% reduction in the rate of change of ventricular dimensions and wall thickness.
Conclusions:
- M-mode echocardiography is a reliable method for assessing left ventricular mass in baboons.
- Chronic hypertension induces concentric cardiac hypertrophy in baboons, which preserves left ventricular stress but impairs systolic and diastolic function.