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Related Experiment Video

Updated: Aug 25, 2025

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis
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Label-free highly multimodal nonlinear endoscope.

D Septier, V Mytskaniuk, R Habert

    Optics Express
    |October 14, 2022
    PubMed
    Summary
    This summary is machine-generated.

    We developed a compact micro-endoscope for label-free biological tissue imaging. This device enables multimodal nonlinear microscopy, including multiphoton fluorescence, harmonic generation, and CARS imaging with high resolution.

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    Area of Science:

    • Biomedical Optics
    • Microscopy
    • Materials Science

    Background:

    • Label-free imaging is crucial for understanding biological tissues without exogenous agents.
    • Multimodal nonlinear microscopy offers complementary information for comprehensive tissue analysis.
    • Miniaturized endoscopic systems are needed for in-situ and in-vivo imaging applications.

    Purpose of the Study:

    • To demonstrate a highly multimodal nonlinear micro-endoscope for label-free biological tissue imaging.
    • To integrate multiple nonlinear imaging modalities within a compact endoscopic platform.
    • To achieve high-resolution imaging of unlabeled biological tissues.

    Main Methods:

    • Development of a 2 mm diameter micro-endoscope utilizing a double-clad antiresonant hollow core fiber.
    • Functionalization with a graded-index (GRIN) fiber and GRIN micro-objective for enhanced optical performance.
    • Implementation of multiphoton fluorescence (3-photon, 2-photon), harmonic generation (SHG, THG), and CARS imaging techniques.

    Main Results:

    • The micro-endoscope achieved a 1.1 µm point spread function (PSF) for high-resolution imaging.
    • Demonstrated label-free imaging capabilities across multiple nonlinear modalities: 3-photon, 2-photon, THG, SHG, and CARS.
    • Acquired high-resolution images of unlabeled biological tissues, showcasing the system's efficacy.

    Conclusions:

    • The developed micro-endoscope provides a versatile platform for multimodal label-free tissue imaging.
    • The compact design and integrated nonlinear optical techniques enable advanced biomedical diagnostics.
    • This technology holds potential for minimally invasive in-situ tissue characterization.