Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.3K
Stem Cell Niche01:26

Stem Cell Niche

5.2K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.2K
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.7K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.7K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.2K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.2K
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

1.8K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
1.8K
Aging01:26

Aging

154
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
154

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical and early biochemical responses to botulinum toxin type-A in refractory masticatory myofascial pain: a pilot single-arm study.

BMC oral health·2026
Same author

Mucosal Wetness, Hyposalivation, and Local Defense in Periodontal Inflammation.

Oral diseases·2025
Same author

The effect of the combination therapy with chlorophyllin, a glutathione transferase P1-1 inhibitor, and docetaxel on triple-negative breast cancer invasion and metastasis in vivo/in vitro.

Naunyn-Schmiedeberg's archives of pharmacology·2025
Same author

Investigation of the inhibitory effects of the telomere-targeted compounds on glutathione S-transferase P1.

Naunyn-Schmiedeberg's archives of pharmacology·2025
Same author

Effects of Photobiomodulation Application on Glutathione-Related Antioxidant Defense System in Rabbit Eye Tissues.

Journal of biophotonics·2024
Same author

Cross talk between genetics and biochemistry in the pathogenesis of hepatocellular carcinoma.

Hepatology forum·2024

Related Experiment Video

Updated: Aug 25, 2025

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

2.0K

Stem Cell and Oxidative Stress-Inflammation Cycle.

Hatice Dogan Buzoglu1,2, Ayse Burus2, Yasemin Bayazıt2

  • 1Department of Endodontics, Faculty of Dentistry, Hacettepe University, Ankara, Turkey.

Current Stem Cell Research & Therapy
|October 14, 2022
PubMed
Summary

Mesenchymal stromal/stem cells (MSCs) are vital for tissue engineering and repair. Oxidative stress and inflammation negatively impact MSC function, highlighting the need for therapies targeting these processes for better treatment outcomes.

Keywords:
Mesenchymal stem cellsROSdental pulp stem cellsinflammationoxidative stressreactive nitrogen species (RNS)

More Related Videos

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
09:31

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe

Published on: September 17, 2021

4.1K
Analysis of Oxidative Stress in Zebrafish Embryos
11:05

Analysis of Oxidative Stress in Zebrafish Embryos

Published on: July 7, 2014

37.3K

Related Experiment Videos

Last Updated: Aug 25, 2025

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

2.0K
Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
09:31

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe

Published on: September 17, 2021

4.1K
Analysis of Oxidative Stress in Zebrafish Embryos
11:05

Analysis of Oxidative Stress in Zebrafish Embryos

Published on: July 7, 2014

37.3K

Area of Science:

  • Stem cell biology
  • Regenerative medicine
  • Oxidative stress research

Background:

  • Mesenchymal stromal/stem cells (MSCs) are multipotent stem cells crucial for tissue engineering and repair.
  • Oxidative stress, caused by reactive oxygen and nitrogen species, damages cellular components and is linked to inflammation.
  • Inflammation exacerbates oxidative stress, negatively impacting stem cell differentiation and regenerative processes.

Purpose of the Study:

  • To review the role of oxidative stress and inflammation in mesenchymal stromal/stem cell (MSC) function.
  • To explore the therapeutic potential of dental pulp stem cells (DPSCs) in various diseases.
  • To discuss the implications of oxidative stress-inflammation cycle and senolysis in age-related diseases.

Main Methods:

  • Literature review on stem cell biology, oxidative stress, and inflammation.
  • Analysis of studies investigating mesenchymal stromal/stem cells (MSCs) from various sources.
  • Examination of research on dental pulp stem cells (DPSCs) and their therapeutic applications.

Main Results:

  • Oxidative stress and inflammation impair MSC vitality, differentiation, and regenerative capabilities.
  • Dental pulp stem cells (DPSCs) show promise for treating neurological, cardiological, and inflammatory conditions.
  • Targeting the oxidative stress-inflammation cycle and employing senolysis are potential future therapeutic strategies.

Conclusions:

  • Understanding the interplay between oxidative stress and inflammation is critical for enhancing MSC-based therapies.
  • Dental pulp stem cells (DPSCs) represent a promising cell source for regenerative medicine.
  • Senolysis offers a novel approach to combat age-related diseases by eliminating senescent cells.