Anti-Mi2 Antibody Positive Dermatomyositis With Hyper-Elevated Creatine Kinase: A Case Report

Area of Science:

• Rheumatology
• Immunology
• Dermatology

Background:

• Dermatomyositis (DM) is a rare autoimmune myopathy impacting middle-aged and older individuals.
• Clinical manifestations of DM are often correlated with specific autoantibody profiles.
• Early diagnosis and intervention are critical for managing disease progression and improving quality of life.

Observation:

• A 65-year-old female presented with severe muscular symptoms lasting three months.
• The patient was diagnosed with anti-Mi-2 antibody-positive dermatomyositis.
• Initial presentation included extremely high creatine kinase levels.

Findings:

• The patient received a combination therapy including prednisolone, azathioprine, and intravenous immunoglobulins.
• Successful treatment resulted in significant improvement of muscular findings and overall condition.
• This case underscores the efficacy of multi-modal treatment in severe DM.

Implications:

• Highlights the importance of prompt and aggressive treatment for DM, especially with elevated creatine kinase.
• Emphasizes the need for patient education on symptom recognition and seeking timely medical help, particularly in rural older populations.
• Suggests that early intervention can prevent irreversible damage and long-term disability associated with autoimmune myopathies.