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Updated: Aug 25, 2025

Quantification of Hypopigmentation Activity In Vitro
Published on: March 6, 2019
Hyperpigmentation as a Primary Symptom of Vitamin B12 Deficiency: A Case Report
Anzal Jangda1, Diana Voloshyna2, Krishna Ramesh3
1Internal Medicine, Ziauddin University, Karachi, PAK.
Abstract:
The presentation of vitamin B12 deficiency varies from being asymptomatic to affecting multiple organ systems. In addition, several systemic diseases can be associated with generalized weakness and hyperpigmentation. However, vitamin B12 deficiency rarely presents with hyperpigmentation as an initial symptom. We present a rare case of a 22-year-old college student who presented with hyperpigmentation as the only physical manifestation of early vitamin B12 deficiency. This case underlines the need to rule out vitamin B12 deficiency when clinicians encounter hyperpigmentation as a solo presentation and also emphasizes the significance of early treatment in preventing the irreversible neurological manifestations of vitamin B12 deficiency.
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