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Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells
Published on: November 17, 2017
A Review on Effectiveness of Plasma Therapy in Severe COVID-19 Patients
Kartik Kapil1, Pramita Muntode Gharde2
1Department of Community Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (DU), Wardha, IND.
Abstract:
Coronavirus 2019 has created a big threat to the modern world. Many researchers and scientists had taken the burden of finding information about this entity, its structure, its transmission, and also about the treatment that can be given to individuals infected by it. There has been use of different medicines at different times simultaneously researching about them, starting with only symptomatic and supportive treatment, then antimalarial agents like chloroquine and hydroxychloroquine, then going to favipavir, and other antivirals, then came the use of vaccines and also convalescent plasma therapy for COVID-19. The most advanced is convalescent plasma use for the treating coronavirus. Using plasma of patients who have remitted from this disease and putting it into those individuals who are dealing with the disease or are critically ill for improvement of their health status. This treatment has been used for many other diseases too and has been proven efficacious. So, this technique is being used and studied for coronavirus 2019 as well. There have been set certain criteria for those who can donate plasma and also criteria for the recipients of this technique. Also, there can be adverse reactions or even side effects with this, like transfusion-related acute lung injury (TRALI), so they should also be kept in mind during treatment with this method. So, though there are many methods to date to treat these individuals but one of the latest ones is using plasma, which is proven to be efficacious but still many studies are under process for the same.
Insights
Convalescent plasma therapy, using plasma from recovered COVID-19 patients, is an advanced treatment option. This therapy shows efficacy for severe coronavirus disease 2019 (COVID-19) but requires further study.
Area of Science:
- Infectious Diseases
- Immunology
- Transfusion Medicine
Background:
- Coronavirus disease 2019 (COVID-19) poses a significant global health threat.
- Research has explored various treatments, including symptomatic care, antimalarials, antivirals, vaccines, and convalescent plasma therapy.
- Convalescent plasma therapy has a history of use in other diseases and is being investigated for COVID-19.
Purpose of the Study:
- To evaluate the use and efficacy of convalescent plasma therapy for treating COVID-19.
- To review the criteria for plasma donation and recipient selection.
- To identify potential adverse reactions associated with convalescent plasma therapy.
Main Methods:
- Administration of plasma from recovered COVID-19 patients to critically ill individuals.
- Establishing donor and recipient eligibility criteria.
- Monitoring for potential side effects, such as transfusion-related acute lung injury (TRALI).
Main Results:
- Convalescent plasma therapy is an advanced treatment approach for COVID-19.
- The therapy has demonstrated efficacy in improving the health status of infected individuals.
- Established criteria exist for both plasma donors and recipients.
Conclusions:
- Convalescent plasma therapy is a promising and efficacious treatment for COVID-19.
- Potential adverse effects, including TRALI, must be considered.
- Ongoing studies are crucial to further validate and refine this therapeutic strategy.
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