Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomics02:02

Genomics

36.9K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.9K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

14.0K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.0K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

15.6K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.6K
Next-generation Sequencing03:00

Next-generation Sequencing

92.3K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
92.3K
Human Genetics01:28

Human Genetics

685
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
685
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

47.5K
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
47.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enabling scale and spread of technology-enabled remote monitoring of blood pressure at home: findings from a rapid qualitative evaluation.

NIHR open research·2026
Same author

Effect of can damage on element migration into meat products during storage and the associated health risks.

Food chemistry·2026
Same author

Gender Differences in Anti-Doping Rule Violations Based on a 19-Year Data Analysis from the Serbian Anti-Doping Agency: National Study.

Sports (Basel, Switzerland)·2025
Same author

Implementation and use of technology-enabled remote monitoring for chronic obstructive pulmonary disease: a rapid qualitative evaluation.

Health and social care delivery research·2025
Same author

Experiential learning from rapid evaluation in health and care.

Journal of health services research & policy·2025
Same author

Adopting and embedding home sensors in social care: findings from a mixed methods, rapid evaluation.

NIHR open research·2025

Related Experiment Video

Updated: Aug 25, 2025

Validating Whole Genome Nanopore Sequencing, using Usutu Virus as an Example
05:45

Validating Whole Genome Nanopore Sequencing, using Usutu Virus as an Example

Published on: March 11, 2020

8.9K

COVID-19 Genomics UK (COG-UK) Consortium: Final Report.

Sonja Marjanovic, Robert J Romanelli, Gemma-Claire Ali

    Rand Health Quarterly
    |October 14, 2022
    PubMed
    Summary

    The COVID-19 Genomics UK (COG-UK) Consortium rapidly advanced SARS-CoV-2 variant understanding to inform public health policy. This evaluation assessed its contributions to scientific knowledge and its impact on policy decisions.

    Keywords:
    BiosurveillanceCoronavirus Disease 2019 (COVID-19)Genomic MedicinePandemicUnited Kingdom

    More Related Videos

    Author Spotlight: A Cost-Effective Genomic Workflow for Advancing Rabies Control in Resource-Limited Settings
    10:26

    Author Spotlight: A Cost-Effective Genomic Workflow for Advancing Rabies Control in Resource-Limited Settings

    Published on: August 18, 2023

    5.4K
    Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing
    10:18

    Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing

    Published on: October 16, 2018

    12.2K

    Related Experiment Videos

    Last Updated: Aug 25, 2025

    Validating Whole Genome Nanopore Sequencing, using Usutu Virus as an Example
    05:45

    Validating Whole Genome Nanopore Sequencing, using Usutu Virus as an Example

    Published on: March 11, 2020

    8.9K
    Author Spotlight: A Cost-Effective Genomic Workflow for Advancing Rabies Control in Resource-Limited Settings
    10:26

    Author Spotlight: A Cost-Effective Genomic Workflow for Advancing Rabies Control in Resource-Limited Settings

    Published on: August 18, 2023

    5.4K
    Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing
    10:18

    Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing

    Published on: October 16, 2018

    12.2K

    Area of Science:

    • Pathogen genomics
    • Viral variant analysis
    • Public health genomics

    Background:

    • The emergence of SARS-CoV-2 necessitated rapid genomic surveillance.
    • The COVID-19 Genomics UK (COG-UK) Consortium was established to study virus variants.
    • Understanding viral evolution is critical for effective public health responses.

    Purpose of the Study:

    • To evaluate the CCOVID-19 Genomics UK (COG-UK) Consortium's performance against its objectives.
    • To assess COG-UK's contribution to scientific knowledge on SARS-CoV-2.
    • To examine the impact of COG-UK on public health policy and decision-making.

    Main Methods:

    • Qualitative evaluation of the COG-UK Consortium's operations.
    • Analysis of COG-UK's contributions to scientific understanding of SARS-CoV-2 variants.
    • Assessment of factors influencing COG-UK's progress and impact.

    Main Results:

    • COG-UK significantly advanced scientific knowledge regarding SARS-CoV-2 variants.
    • The consortium provided crucial data informing public health decisions and policy.
    • Evaluation identified key enablers and challenges impacting the consortium's effectiveness.

    Conclusions:

    • The COG-UK Consortium played a vital role in understanding SARS-CoV-2 evolution and informing the pandemic response.
    • Genomic surveillance collaborations are essential for managing public health crises.
    • Lessons learned can inform future pathogen genomics initiatives.