Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.0K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K
Cancer Therapies02:49

Cancer Therapies

7.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.9K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

7.7K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.7K
Cancer Vaccines01:30

Cancer Vaccines

488
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
488

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GT198 Is a Target of Oncology Drugs and Anticancer Herbs.

Frontiers in oral health·2021
Same journal

Associations between traditional Chinese medicine body constitution and obesity risk among US adults.

Longhua Chinese medicine·2024
Same journal

Effects of saffron and its active constituent crocin on cancer management: A narrative review.

Longhua Chinese medicine·2023
Same journal

<i>Artemisia</i> annua and artemisinins are ineffective against human <i>Babesia microti</i> and six <i>Candida</i> sp.

Longhua Chinese medicine·2021
See all related articles

Related Experiment Video

Updated: Aug 25, 2025

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer
06:24

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

1.0K

Decoding cancer and herbal renaissance.

Lan Ko1,2

  • 1Research and Development, OnkoTarget LLC, Augusta, GA, USA.

Longhua Chinese Medicine
|October 14, 2022
PubMed
Summary
This summary is machine-generated.

Researchers resolved the cancer target paradox by identifying pericyte stem cells expressing GT198 as the origin of solid tumors. This discovery enables screening of herbal medicines for effective cancer treatment.

Keywords:
GT198Herbsanticancerdrug target

More Related Videos

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
09:03

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula

Published on: January 26, 2024

440
Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
08:32

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Published on: May 23, 2025

399

Related Experiment Videos

Last Updated: Aug 25, 2025

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer
06:24

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

1.0K
Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
09:03

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula

Published on: January 26, 2024

440
Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
08:32

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Published on: May 23, 2025

399

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Herbal Medicine

Background:

  • The search for cancer targets has been hindered by a paradox: cancer stem cells and their target proteins are difficult to identify independently.
  • Solid tumors originate in the tumor microenvironment from rare stem cells expressing a specific mutant target protein.

Purpose of the Study:

  • To resolve the cancer target paradox by integrating evidence from multiple scientific disciplines.
  • To identify the specific stem cells and target proteins involved in solid tumor initiation.
  • To establish a unified theory of cancer and disease centered on pericyte stem cells.

Main Methods:

  • Reviewed and synthesized evidence from genetics, pathology, stem cell biology, clinical oncology, and herbal medicine.
  • Investigated the role of stem cells in the tumor microenvironment and angiogenesis.
  • Identified GT198 (PSMC3IP/Hop2) as a key target protein in pericyte stem cells.

Main Results:

  • Resolved the chicken-egg paradox by identifying pericyte stem cells as the origin of solid tumors.
  • GT198, a DNA repair factor and transcriptional regulator, was identified as a specific target protein in these pericyte stem cells.
  • GT198 is a direct drug target for chemotherapy drugs and anticancer herbs.

Conclusions:

  • Pericyte stem cells and their target protein GT198 provide a unified understanding of cancer and disease.
  • This discovery opens avenues for screening herbal medicines against GT198 for effective cancer therapy.
  • A new approach to identifying multi-functional herbs is established, potentially leading to a renaissance in herbal medicine for cancer treatment.