Related Experiment Video

Updated: Jul 29, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

52.7K

Correlation of Serum M-CSF, CER, and TIMP-1 Levels with Liver Fibrosis in Viral Hepatitis

Hairong Yao1, Xuan Yang2, Man Yan3

  • 1Department of Cardiology, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, Shaanxi 710018, China.

Computational and Mathematical Methods in Medicine
|October 14, 2022
PubMed
Abstract

Insights

This study shows that serum levels of macrophage colony-stimulating factor (M-CSF), tissue inhibitor of matrix metalloproteinase (TIMP-1), and ceruloplasmin (CER) correlate with liver fibrosis in chronic hepatitis B (CHB) patients. Combined detection of these markers improves diagnostic accuracy for liver fibrosis.

Area of Science:

  • Hepatology
  • Biochemistry
  • Immunology

Background:

  • Chronic hepatitis B (CHB) is a significant cause of liver fibrosis.
  • Accurate assessment of liver fibrosis is crucial for patient management.
  • Biomarkers for non-invasively staging liver fibrosis are needed.

Purpose of the Study:

  • To investigate the relationship between liver fibrosis in CHB and serum levels of macrophage colony-stimulating factor (M-CSF), tissue inhibitor of matrix metalloproteinase (TIMP-1), and ceruloplasmin (CER).
  • To evaluate the diagnostic utility of these markers, individually and in combination, for assessing liver fibrosis severity.

Main Methods:

  • Serum levels of M-CSF, CER, and TIMP-1 were measured in CHB patients and healthy controls.
  • CHB patients were stratified into four fibrosis groups (S1-S4).
  • Statistical analyses correlated marker levels with fibrosis stage and assessed diagnostic performance using Area Under the Curve (AUC).

Main Results:

  • Serum M-CSF and TIMP-1 levels were elevated, while CER levels were decreased in CHB patients compared to controls.
  • Significant differences in M-CSF, CER, TIMP-1, and other fibrosis markers (HA, PC-III, C-IV, LN) were observed across fibrosis stages.
  • Progressive liver fibrosis was associated with increasing M-CSF, TIMP-1, and decreasing CER levels, with significant correlations.

Conclusions:

  • Serum M-CSF, CER, and TIMP-1 levels are significantly associated with the degree of liver fibrosis in CHB patients.
  • The combined assessment of M-CSF, CER, and TIMP-1 demonstrates superior diagnostic significance for staging liver fibrosis compared to individual markers.
  • These markers offer potential as non-invasive tools for monitoring liver fibrosis progression in CHB.

More Related Videos

Induction of an Inflammatory Response in Primary Hepatocyte Cultures from Mice08:32

Induction of an Inflammatory Response in Primary Hepatocyte Cultures from Mice

Published on: March 10, 2017

10.2K
Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

10.2K

Related Concept Videos

Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...