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An Individualized Approach to Managing Testosterone Therapy in the Primary Care Setting.

Adrian Sandra Dobs1, Kevin James Campbell2

  • 1Division of Endocrinology, Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

International Journal of General Medicine
|October 14, 2022
PubMed
Summary
This summary is machine-generated.

Testosterone therapy is increasingly prescribed by primary care physicians for testosterone deficiency. An individualized approach is essential due to diverse formulations and patient factors.

Keywords:
clinical practicecomorbidityhypogonadismmaletestosterone deficiency

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Area of Science:

  • Endocrinology
  • Primary Care Medicine
  • Pharmacology

Background:

  • Rising incidence of testosterone deficiency and increased testosterone therapy prescriptions.
  • Primary care physicians are the main prescribers in the US and Canada.
  • Wider availability of diverse testosterone formulations with unique characteristics.

Purpose of the Study:

  • To review the current landscape of testosterone therapy.
  • To address concerns regarding efficacy, safety, and specific patient populations.
  • To emphasize the need for individualized treatment approaches.

Main Methods:

  • Literature review of clinical trials and research on testosterone therapy.
  • Analysis of available testosterone formulations and their properties.
  • Examination of potential risks and benefits in various patient groups.

Main Results:

  • Testosterone therapy is generally effective and safe in clinical trials.
  • Concerns persist regarding fertility, prostate cancer, polycythemia, and cardiovascular events.
  • Ongoing research focuses on specific populations like older adults, obese patients with type 2 diabetes, and transgender individuals.

Conclusions:

  • Individualized testosterone therapy is crucial, considering patient goals, comorbidities, and formulation characteristics.
  • Further research is needed to fully understand effects in diverse populations.
  • Balancing benefits and risks requires a personalized treatment strategy.