Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recommended precautions when using low-osmolality or nonionic contrast agents with vasodilators.

R J Zagoria, V J D'Souza, A L Baker

    Investigative Radiology
    |June 1, 1987
    PubMed
    Summary

    Low-osmolality contrast agents may be incompatible with common angiography vasodilators. Testing revealed precipitate formation with Hexabrix and papaverine, and immiscibility with Hexabrix and tolazoline. A flush solution is advised to prevent adverse reactions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Reactive intermediate phase cold sintering in strontium titanate.

    RSC advances·2022
    Same author

    'Summer of Sport': the development of a 6-week programme in increasing physical activity to improve public health outcomes.

    Public health·2019
    Same author

    Alcohol Text Messages: A Developmental Study.

    International journal of mental health and addiction·2018
    Same author

    01-05 Cannabis use history and onset to psychosis in an ultrahigh-risk group.

    Acta neuropsychiatrica·2016
    Same author

    The iTreAD project: a study protocol for a randomised controlled clinical trial of online treatment and social networking for binge drinking and depression in young people.

    BMC public health·2015
    Same author

    Laparoscopic common bile duct exploration.

    The British journal of surgery·2014

    Area of Science:

    • Radiology
    • Pharmacology
    • Chemical Engineering

    Background:

    • Angiography frequently utilizes low-osmolality contrast agents.
    • Vasodilators are commonly co-administered during angiographic procedures.
    • Potential chemical interactions between these agents require investigation.

    Purpose of the Study:

    • To assess the chemical compatibility of low-osmolality contrast agents with frequently used vasodilators.
    • To identify potential adverse reactions or incompatibilities during co-administration.

    Main Methods:

    • Low-osmolality contrast agents were mixed with specific vasodilators (papaverine, tolazoline).
    • Visual inspection for precipitate formation and immiscibility was performed.
    • Standard laboratory testing protocols for chemical compatibility were employed.

    Related Experiment Videos

    Main Results:

    • A distinct white crystalline precipitate formed when Hexabrix was mixed with papaverine.
    • Transient immiscibility was observed between Hexabrix and tolazoline.
    • No other significant incompatibilities were noted with the tested agents.

    Conclusions:

    • Chemical incompatibility exists between certain low-osmolality contrast agents and vasodilators.
    • The observed precipitate and immiscibility highlight risks during co-administration.
    • A precautionary measure of injecting a flush solution between vasodilator and contrast agent is recommended.