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Bibliometric analysis of fibroblast growth factor 21 research over the period 2000 to 2021

Qin-Ying She1, Li-Juan Li1, Ming-Hong Liu1

  • 1Department of Nephrology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China.

Frontiers in Pharmacology
|October 14, 2022
PubMed

Insights

Fibroblast growth factor 21 (FGF-21) research shows peripheral metabolic effects and drug development are key topics. Emerging trends include central FGF-21 effects and non-metabolic disease impacts.

Area of Science:

  • Metabolic Regulation
  • Endocrinology
  • Pharmacology

Background:

  • Fibroblast growth factor 21 (FGF-21) is a key metabolic regulator with significant pharmacological potential.
  • Despite extensive research, clinical trial outcomes for FGF-21 have been inconsistent, prompting further investigation into its therapeutic value.

Purpose of the Study:

  • To conduct a bibliometric analysis of FGF-21 research over the past 20 years.
  • To identify key research topics, influential contributors, and emerging trends in the field.
  • To evaluate the current state and future directions of FGF-21 research.

Main Methods:

  • Collected 2,490 publications on FGF-21 from the Web of Science Core Collection (Science Citation Index Expanded).
  • Utilized HistCite, VOSviewer, and CiteSpace for bibliometric analysis and visualization.
  • Analyzed publication trends, leading countries, institutions, authors, journals, and keywords.

Main Results:

  • Research on FGF-21 has involved 12,872 authors from 2,628 institutions across 77 countries.
  • The United States led in FGF-21 research, with Alexei Kharitonenkov, Steven A. Kliewer, and David J. Mangelsdorf as highly influential scholars.
  • Key research areas included physiological roles, clinical translation, and FGF-21 drug development, with endocrinology journals being central.

Conclusions:

  • Peripheral metabolic effects, drug development, and translational research on metabolic diseases are the primary focuses in FGF-21 studies.
  • Future research is expected to concentrate on central FGF-21 effects and its impact on non-metabolic diseases, representing emerging trends.
Keywords:
CitespaceHistciteVOSviewerbibliometric analysisfibroblast growth factor 21

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