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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Predictors of a Favorable Outcome after Emergent Carotid Artery Stenting in Acute Anterior Circulation Stroke
Insights
Predictors of good outcomes after emergent carotid artery stenting (CAS) for acute stroke were identified. Baseline infarct size, successful reperfusion, and parenchymal hemorrhage significantly influenced patient recovery following CAS.
Area of Science:
- Neurology
- Interventional Cardiology
- Vascular Surgery
Background:
- Acute anterior circulation stroke poses a significant health burden.
- Emergent carotid artery stenting (CAS) is a critical intervention for selected stroke patients.
- Identifying predictors of favorable outcomes is crucial for optimizing CAS treatment strategies.
Purpose of the Study:
- To identify independent predictors of favorable outcomes in patients undergoing emergent CAS for acute anterior circulation stroke.
- To analyze factors associated with successful recovery (modified Rankin Scale 0-2 at 90 days).
Main Methods:
- A cohort of 93 patients with acute stroke undergoing emergent CAS within 6 hours of symptom onset was studied.
- Data were compared between patients with and without favorable outcomes.
- Logistic regression analysis was employed to determine independent predictors of favorable outcomes.
Main Results:
- Intracranial tandem occlusion was present in 81.7% of patients.
- Successful intracranial reperfusion was achieved in 74.2% of patients, with 51.6% experiencing favorable outcomes.
- Independent predictors of favorable outcomes included a higher diffusion-weighted imaging-Alberta Stroke Program Early CT Score (OR, 1.487), successful reperfusion (OR, 5.199), and absence of parenchymal hemorrhage (OR, 0.042).
Conclusions:
- Baseline infarct size, successful reperfusion, and parenchymal hemorrhage are independent predictors of favorable outcomes after emergent CAS.
- These findings aid in patient selection and risk stratification for emergent CAS in acute stroke.
Purpose:
This study aimed to identify independent predictors of favorable outcomes associated with emergent carotid artery stenting (CAS) in patients with acute anterior circulation stroke.
Materials And Methods:
This study included 93 patients with acute stroke who underwent emergent CAS to treat stenoocclusive lesions in the cervical internal carotid artery (ICA) within 6 hours of the onset of the associated symptoms. Data were compared between patients with and without favorable outcomes. The independent predictors of a favorable outcome were determined via logistic regression analysis (modified Rankin Scale 0-2 at 90 days).
Results:
Intracranial tandem occlusion was noted in 81.7% of patients (76/93) among which (76/93), 55 of whom underwent intracranial recanalization therapy. Intracranial reperfusion was successful in 74.2% (69/93) and favorable outcomes were noted in 51.6% of patients (48/93). The mortality rate was 6.5% (6/93). In logistic regression analysis, diffusion-weighted imaging-Alberta Stroke Program Early CT Score [odds ratio (OR), 1.487; 95% confidence interval (CI), 1.018-2.173, p = 0.04], successful reperfusion (OR, 5.199; 95% CI, 1.566-17.265, p = 0.007), and parenchymal hemorrhage (OR, 0.042; 95% CI, 0.003-0.522, p = 0.014) were independently associated with a favorable outcome.
Conclusion:
Baseline infarct size, reperfusion status, and parenchymal hemorrhage were independent predictors of favorable outcomes after emergent CAS to treat stenoocclusive lesions in the cervical ICA in patients with acute anterior circulation stroke.
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