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Maternal pre-eclampsia as a risk factor for developing bronchopulmonary dysplasia in neonates
Niraj Vora1, Muppala Raju2, Ineshia Jackson1
1Department of Pediatrics, Texas A&M Health Science Center, Baylor Scott & White Health, Temple, TX, USA.
Maternal pre-eclampsia did not increase the risk of bronchopulmonary dysplasia (BPD) in preterm infants. However, infants with intrauterine growth restriction (IUGR), regardless of maternal pre-eclampsia, faced a higher risk of BPD.
Area of Science:
- Neonatal Medicine
- Perinatal Health
- Respiratory Medicine
Background:
- Bronchopulmonary dysplasia (BPD) is a significant complication in preterm infants.
- Pre-eclampsia, a hypertensive disorder of pregnancy, may impact fetal development and neonatal outcomes.
Purpose of the Study:
- To investigate the association between maternal pre-eclampsia and the incidence of BPD in preterm infants.
- To identify risk factors for BPD development in a cohort of very preterm neonates.
Main Methods:
- Retrospective cohort study of infants born at ≤32 weeks' gestation.
- Infants were stratified based on maternal pre-eclampsia status.
- Logistic regression analysis was employed to determine predictors of BPD.
Main Results:
- Pre-eclampsia was not found to be a significant risk factor for BPD development (OR 1.12 [0.68, 1.83]).
- Infants born to mothers with pre-eclampsia had lower birth weights and higher rates of cesarean delivery.
- Higher incidence of intrauterine growth restriction (IUGR) was observed in the pre-eclampsia group (24% vs. 8%).
Conclusions:
- Maternal pre-eclampsia is not a direct risk factor for BPD in preterm infants.
- Infants with IUGR, irrespective of maternal pre-eclampsia, exhibit an elevated risk for BPD.
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