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Updated: Aug 25, 2025
Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression
Published on: February 3, 2023
PET Imaging of Self-Assembled 18 F-Labelled Pd2 L4 Metallacages for Anticancer Drug Delivery
Raúl Cosialls1,2, Cristina Simó3,2, Salvador Borrós4
1BISi-Bonds group, Dept. of Organic and Pharmaceutical Chemistry, Institut Químic de Sarrià, URL, Vía Augusta 390, 08017, Barcelona, Spain.
Abstract:
To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18 F-labelled [Pd2 L4 ]4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.
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