Related Experiment Video

Updated: Aug 25, 2025

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro
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Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro

Published on: June 6, 2025

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Cell Entry and Unusual Replication of SARS-CoV-2

Nathan McCann1, Francis J Castellino1

  • 1Department of Chemistry and Biochemistry and W.M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46530, USA.

Current Drug Targets
|October 14, 2022
PubMed
Summary

This review summarizes the complex replication mechanisms of SARS-CoV-2, the virus causing COVID-19. Understanding viral replication, especially the spike protein

Keywords:
SARS-CoV-2programmed frame shiftprotein domainsspike proteinsubgenomic RNAviral cell entryviral replication

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