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Pigmented Multinucleate Cell Angiohistiocytoma: First Case.

Angel Fernandez-Flores^1,2,3, David Cassarino⁴

¹Department of Histopathology, University Hospital El Bierzo, Ponferrada, Spain.

The American Journal of Dermatopathology

|October 14, 2022

Summary

A rare pigmented variant of multinucleate cell angiohistiocytoma (MCAH) was identified. This benign skin condition features peculiar multinucleate cells containing melanin pigment.

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Area of Science:

Dermatopathology
Histology
Pigmentary disorders

Background:

Multinucleate cell angiohistiocytoma (MCAH) is a benign vascular and fibrohistiocytic proliferation.
Its characteristic multinucleate cells are typically interpreted as degenerated macrophages.
Clinical variants exist, some presenting with brownish lesions.

Observation:

A case of pigmented MCAH in a 33-year-old woman is presented.
Multiple papules and plaques were observed on the right elbow, jawline, and left flank.
Cytoplasmic brownish pigment was noted within the multinucleate cells.

Findings:

The pigment stained positive with Masson-Fontana stain.
The pigment was negative with iron staining.
Histological findings are consistent with melanin deposition in the multinucleate cells.

Implications:

This case expands the known histological spectrum of MCAH.
It highlights the presence of melanin within the multinucleate cells of MCAH.
Further research may clarify the origin and significance of melanin in this condition.