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Updated: Aug 25, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
Supraventricular tachyarrhythmia and sinus node dysfunction as a first manifestation of short QT syndrome in a
Ruy G Ploneda-Valencia1, Willian A Ortiz-Solis1, Gustavo Ruiz-Gonzalez1
1Department of Electrophysiology, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico City, Mexico.
Abstract:
Short QT syndrome (SQTS) represents a diagnosis challenge where the symptoms may vary from palpitations in an otherwise asymptomatic patient to sudden death. Is a recently discovered rare channelopathy, identified by Gussak in 2000, characterized by short QT intervals on the electrocardiogram and a tendency to develop atrial and ventricular arrhythmias in the absence of structural heart disease, hyperkalemia, hypercalcemia, hyperthermia, acidosis and endocrine disorders. We present the case of a 16-year-old patient with short QT-type channelopathy, who presented with sinus arrest and junctional rhythm, who later developed atrial tachycardia and atrial flutter.
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