The knowns and many unknowns of CNS immunity in teleost fish

Many disease agents infect the central nervous system (CNS) of teleost fish causing severe losses for the fish farming sector. Yet, neurotropic fish pathogens remain poorly documented and immune responses in the teleost CNS essentially unknown. Previously thought to be devoid of an immune system, the mammalian CNS is now recognized to be protected from infection by diverse immune cells that mostly reside in the meningeal lymphatic system. Here we review the current body of work pertaining immune responses in the teleost CNS to infection. We identify important knowledge gaps with regards to CNS immunity in fish and make recommendations for rigorous experimentation and reporting in manuscripts so that fish immunologists can advance this burgeoning field.