Influence of stored aqueous ceftriaxone solutions on colony formation by neutrophil and macrophage precursor cells

Aqueous solutions of ceftriaxone in concentrations similar to those achieved in man and stored at temperatures of 4 degrees C, 22 degrees C and 37 degrees C for up to four weeks were tested in methylcellulose cultures of normal bone marrow from ten donors. No significant differences were detected between the colony formation by neutrophil and macrophage precursors in control cultures and in cultures containing stored ceftriaxone. It is concluded that aqueous ceftriaxone solutions stored for up to four weeks at temperatures up to 37 degrees C are not altered to such an extent that they adversely affect colony formation by bone marrow progenitor cells from healthy donors.