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Related Experiment Videos

Respiratory changes in thoracic muscle length during bronchoconstriction.

E van Lunteren, M A Haxhiu, E C Deal

    Journal of Applied Physiology (Bethesda, Md. : 1985)
    |July 1, 1987
    PubMed
    Summary

    Bronchoconstriction impairs diaphragm and intercostal muscle shortening despite increased electrical activity. This suggests respiratory muscle function is compromised during airway constriction.

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    Area of Science:

    • Respiratory Physiology
    • Muscle Mechanics
    • Pulmonary Medicine

    Background:

    • Bronchoconstriction significantly increases airway resistance.
    • Understanding respiratory muscle response to bronchoconstriction is crucial for managing respiratory diseases.

    Purpose of the Study:

    • To evaluate the impact of bronchoconstriction on the length changes of the costal diaphragm and parasternal intercostal muscles.
    • To investigate the relationship between respiratory muscle electrical activity and mechanical shortening during bronchoconstriction.

    Main Methods:

    • Anesthetized dogs underwent tracheostomy and were subjected to histamine-induced bronchoconstriction.
    • Respiratory muscle length changes were measured using sonomicrometry.
    • Electromyograms (EMG) were recorded to assess muscle electrical activity.

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    Main Results:

    • Histamine increased pulmonary resistance and reduced inspiratory/expiratory times and tidal volume.
    • Peak and rate of rise of respiratory muscle EMG activity increased significantly.
    • Despite increased EMG, diaphragm and intercostal muscle inspiratory shortening were reduced, with decreased velocity-to-EMG ratios.

    Conclusions:

    • Bronchoconstriction leads to impaired inspiratory shortening of the diaphragm and parasternal intercostal muscles.
    • Increased load, shortened inspiratory time, and potentially reduced resting length contribute to these impairments.
    • These findings highlight compromised respiratory muscle function during bronchoconstriction.