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Brain death due to neuroaspergillosis in a patient with COVID-19

C G Videla1, M Agustina1, P X de la Iglesia Niveyro2

  • 1Adult Intensive Care Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Revista Espanola De Anestesiologia Y Reanimacion
|October 14, 2022
PubMed

Insights

Coinfection with Aspergillus Fumigatus significantly increases COVID-19 patient mortality. This case highlights severe neurological complications, including brain death, from this fungal co-infection.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Critical Care Medicine

Background:

  • Co-infections in COVID-19 patients complicate treatment and prognosis.
  • Aspergillus infections are associated with high morbidity and mortality.

Observation:

  • A patient with COVID-19 developed a concurrent Aspergillus Fumigatus infection.
  • The patient presented with multiple heterogeneous brain lesions.

Findings:

  • The Aspergillus co-infection led to progressive neurological deterioration.
  • Post-mortem biopsy confirmed Aspergillus-compatible pathological lesions in the brain.
  • The patient ultimately experienced brain death.

Implications:

  • This case underscores the critical need to consider and diagnose fungal co-infections in severe COVID-19.
  • Early detection and treatment of Aspergillus in COVID-19 patients may improve outcomes.
  • Further research is needed on managing invasive fungal infections during the COVID-19 pandemic.
Keywords:
Brain deathMuerte cerebralNeuroaspergillosisNeuroaspergilosis

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