Related Experiment Video
Updated: Aug 25, 2025
07:17
Studying Orthodontic Tooth Movement in Mice
Published on: August 2, 2024
873
Do antihypertensive medications effect the mandibular cortical bone thickness? A study using cone beam computed
Brett Spenrath1, Antonia Kolokythas1
1Department of Oral and Maxillofacial Surgery, University of Rochester, Eastman Institute for Oral Health, Rochester, NY, USA.
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
|October 14, 2022
Summary
Antihypertensive medication use is associated with increased mandibular cortical thickness in adults aged 40-69. This finding suggests a potential link between blood pressure medications and bone density in the jaw.
Area of Science:
- Dentistry
- Pharmacology
- Radiology
Background:
- Mandibular cortical thickness is a key indicator of bone health.
- Antihypertensive medications are widely prescribed and can affect bone metabolism.
Purpose of the Study:
- To investigate the association between antihypertensive medication use and mandibular cortical thickness.
- To determine if antihypertensive drugs influence bone density in the mandible.
Main Methods:
- Retrospective cross-sectional study of 169 patients (aged 40-69).
- Cone beam computed tomography (CBCT) scans used to measure buccal cortical thickness of the mandibular ramus.
- Analysis of covariance (ANCOVA) adjusted for age.
Main Results:
- A statistically significant mean difference of 0.21 mm in mandibular cortical thickness was observed between patients using antihypertensive medications and controls (P < .001).
- This association remained significant after adjusting for age.
Conclusions:
- Antihypertensive medication use is associated with increased mandibular cortical thickness.
- Age may modify this effect, potentially increasing the difference in older patients.
