Total organic carbon as an index for specification of water for injection

Determination of organic compounds present as contaminants in purified water is of great importance. Total organic carbon (TOC) may be a useful parameter for evaluating the purity of water. This paper describes and compares the analytical results for solutions of 12 model compounds obtained by 3 methods: total organic carbon (TOC) analysis, determination of potassium permanganate consumption, and UV spectroscopy. TOC analysis gave values corresponding to the expected amounts of organic carbon for all the model compounds, whereas the other 2 methods gave highly variable results.