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Photoexcited wireless electrical stimulation elevates nerve cell growth.

Fangwei Qi1, Ruobing Liao2, Liuyimei Yang3

  • 1Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China; State Key Lab of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China.

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Summary

This study developed wireless electrical stimulation conduits using silver nanoparticles on bismuth sulfide (Ag/Bi2S3) for nerve repair. The enhanced photocurrent effectively promoted nerve cell differentiation and growth.

Keywords:
Laser additive manufacturingNerve guidance conduitPhotocurrentPhotoelectricWireless electrical stimulation

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Neuroscience

Background:

  • Traditional electrical stimulation for nerve repair is limited by external power supplies and wires.
  • Bismuth sulfide (Bi2S3) exhibits photoelectric properties, enabling wireless electrical stimulation via its photocurrent generation.

Purpose of the Study:

  • To develop novel PLLA-Ag/Bi2S3 conduits for wireless electrical stimulation.
  • To enhance photocurrent generation for improved nerve cell growth and differentiation.

Main Methods:

  • In-situ growth of silver nanoparticles (Ag NPs) on Bi2S3 surface to create Ag/Bi2S3.
  • Fabrication of poly-L-lactic acid (PLLA) conduits incorporating Ag/Bi2S3.
  • Electrochemical tests, FDTD simulations, photoluminescence, and EIS measurements to analyze material properties and performance.

Main Results:

  • Ag NPs enhanced photocurrent in PLLA-Ag/Bi2S3 conduits by inhibiting electron-hole recombination and accelerating electron transfer, increasing photocurrent from 0.26 to 1.03 μA.
  • Localized electrical fields generated by Ag NPs improved electron-hole separation in Bi2S3.
  • Enhanced photocurrent promoted cell differentiation by up-regulating Ca2+ influx and SYN1 expression.

Conclusions:

  • PLLA-Ag/Bi2S3 conduits offer a promising approach for wireless electrical stimulation in nerve repair.
  • The synergistic effect of Bi2S3 and Ag NPs significantly boosts photocurrent for enhanced nerve regeneration.