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Related Concept Videos

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
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M cyclin...
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Updated: Aug 25, 2025

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Targeting Cdc20 for cancer therapy.

Seung Min Jeong1, Quyen Thu Bui2, Minseok Kwak3

  • 1Department of Biochemistry, Institute for Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul 06592, Republic of Korea.

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|October 15, 2022
PubMed
Summary
This summary is machine-generated.

The Anaphase-Promoting Complex/Cyclosome (APC/C) regulates cell division. Its co-activator Cdc20, an oncogene, is a potential therapeutic target for cancers driven by cell cycle dysregulation.

Keywords:
CancerCdc20Cell cycleE3 ligasecancer therapy

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • The Anaphase-Promoting Complex/Cyclosome (APC/C) is a crucial E3 ubiquitin ligase regulating cell division.
  • APC/C, with co-activators Cdc20 and Cdh1, controls the degradation of cell cycle regulators.
  • Dysregulation of cell cycle control is linked to uncontrolled proliferation and cancer development.

Purpose of the Study:

  • To review recent findings on the role of APC/C-Cdc20 in cell cycle regulation.
  • To highlight Cdc20's oncogenic properties and its potential as a cancer therapeutic target.

Main Methods:

  • Literature review of recent research on APC/C, Cdc20, and Cdh1.
  • Analysis of the functional roles of APC/C-Cdc20 in cell cycle progression.
  • Summary of findings regarding Cdc20's involvement in tumorigenesis.

Main Results:

  • Cdc20 exhibits oncogenic properties, contrasting with Cdh1's tumor-suppressive role.
  • Strict regulation of Cdc20 expression is essential for proper cell cycle progression.
  • APC/C-Cdc20 plays a critical role in timely and precise cell division.

Conclusions:

  • Cdc20 is an emerging therapeutic target for cancer treatment due to its oncogenic function.
  • Targeting Cdc20 activity may offer beneficial therapeutic interventions for various cancers.
  • Understanding APC/C-Cdc20 regulation is key to developing novel cancer therapies.