Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Viral Mutations00:36

Viral Mutations

32.7K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.7K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

195
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
195
Mutations in Microorganisms01:18

Mutations in Microorganisms

57
Mutations are heritable changes in an organism’s genome involving alterations in the base sequence of DNA or RNA. These changes can influence cellular processes and phenotypic traits, potentially transforming the unaltered wild type into a mutant form. Such changes, termed forward mutations, are pivotal in shaping the genetic diversity of organisms.RNA viruses exhibit the highest mutation rates due to the absence of robust proofreading mechanisms during genome replication. In contrast,...
57
Vaccinations01:51

Vaccinations

45.2K
Overview
45.2K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

15.6K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.6K
Cancer Vaccines01:30

Cancer Vaccines

488
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
488

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Medical students' attitudes, usage patterns, and associated factors with DeepSeek adoption in education: a cross-sectional study in China.

BMC medical education·2026
Same author

Causal Association Between Sarcopenia-Related Traits and COVID-19 Outcomes: A Bidirectional Two-Sample Mendelian Randomization Study.

International journal of rheumatic diseases·2026
Same author

Association of the Intensity, Frequency, Duration, and Volume of Physical Activity With Sarcopenia and Its Related Indicators.

International journal of rheumatic diseases·2026
Same author

CD4 + T cell-derived exosomal miR-223-3p serves as a potential biomarker for systemic lupus erythematosus and attenuates lupus nephritis in NZBWF1/J mice.

Journal of nanobiotechnology·2026
Same author

Unraveling the Complex Roles of Uric Acid in Autoimmune Diseases: Insights into Pathogenesis and Therapeutic Potential.

Current pharmaceutical design·2026
Same author

Transfer RNA-derived small RNAs as potential biomarkers and therapeutic targets for autoimmune diseases.

International immunopharmacology·2026

Related Experiment Video

Updated: Aug 25, 2025

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
06:08

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

1.3K

Novel coronavirus mutations: Vaccine development and challenges.

Wan-Rong Luo1, Xiao-Min Wu1, Wei Wang2

  • 1Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui, China.

Microbial Pathogenesis
|October 15, 2022
PubMed
Summary

This review covers COVID-19 vaccine development and the challenges posed by SARS-CoV-2 mutations. It discusses emerging variants and strategies for effective immunization against evolving coronavirus strains.

Keywords:
GenomicsMutationSARS-CoV-2VaccinationViral

More Related Videos

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses
05:49

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Published on: November 21, 2023

1.8K
A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
08:07

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

2.7K

Related Experiment Videos

Last Updated: Aug 25, 2025

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
06:08

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

1.3K
Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses
05:49

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Published on: November 21, 2023

1.8K
A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
08:07

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

2.7K

Area of Science:

  • Virology
  • Immunology
  • Vaccinology

Background:

  • The COVID-19 pandemic caused by SARS-CoV-2 has had profound global health and economic impacts.
  • Significant progress in vaccine development has led to multiple candidates, with several approved for emergency use.

Purpose of the Study:

  • To review the current landscape of coronavirus vaccine development.
  • To examine the emergence and impact of SARS-CoV-2 variants on vaccine efficacy.
  • To discuss immunization strategies to address viral mutation and diversity.

Main Methods:

  • Literature review of vaccine development and SARS-CoV-2 variant research.
  • Analysis of the prevalence and characteristics of emerging coronavirus variants.
  • Evaluation of the impact of mutations on vaccine protective efficacy.

Main Results:

  • Over 100 vaccine candidates are in clinical trials, with ten WHO-approved vaccines utilizing diverse platforms.
  • Mutations in the SARS-CoV-2 spike protein have led to variants affecting transmissibility, pathogenicity, and immunogenicity.
  • Viral mutations pose challenges to the effectiveness of existing vaccines.

Conclusions:

  • Continued monitoring of SARS-CoV-2 variants is crucial for vaccine development.
  • Adaptation of immunization strategies is necessary to maintain protection against evolving viral strains.
  • Understanding viral mutation is key to long-term pandemic control.