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Updated: Aug 25, 2025

Measuring Liver Mitochondrial Oxygen Consumption and Proton Leak Kinetics to Estimate Mitochondrial Respiration in Holstein Dairy Cattle
Published on: November 30, 2018
Liver Disorders Associated with Metabolic Imbalances in Dairy Cows
Pablo Pinedo1, Pedro Melendez2
1Department of Animal Sciences, Colorado State University, 350 West Pitkin Street, Fort Collins, CO 80253, USA.
Abstract:
This article discusses the complex interrelationships that originated from metabolic stress, triggering unbalances that result in suboptimal liver health. The severe changes occurring around parturition require drastic incrementation in lipolytic activity, leading to significant adipose tissue remodeling. This increased activity ultimately exceeds the liver's normal function. The inability of the liver to perform proper metabolic regulation, together with concurrent inflammatory states, altered immune status, and physiologic imbalances, results in greater risk for disease, lower milk production and fertility, and compromised well-being and lifespan in the herd.
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