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Class I PI3K Biology.

Tihitina Y Aytenfisu1, Hannah M Campbell1, Mayukh Chakrabarti1

  • 1Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.

Current Topics in Microbiology and Immunology
|October 15, 2022
PubMed
Summary
This summary is machine-generated.

This chapter introduces phosphoinositide 3-kinases (PI3K), focusing on class I isoforms. It details PI3K structure, function, signaling pathways, and their roles in diseases and immunotherapies.

Keywords:
APDSArthritisAsthmaB-cell signalingChronic inflammationClass I PI3KsOncogenic mutationPI3KPhosphoinositide-3-kinaseRTK signalingRas signalingT-cell signalingp101p110βp110γp110δp84pl10α

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Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Biochemistry

Background:

  • Phosphoinositide 3-kinases (PI3K) are critical enzymes involved in cellular signaling.
  • Class I PI3Ks are a key focus due to their diverse roles in cell function and disease.

Purpose of the Study:

  • To provide a comprehensive introduction to PI3K, particularly class I isoforms.
  • To detail PI3K structure, function, signaling pathways, and involvement in diseases.

Main Methods:

  • Structural analysis of PI3K isoforms and their subunits.
  • Review of historical investigations into PI3K activity.
  • Examination of PI3K signaling pathways, regulators, and downstream effects.

Main Results:

  • Detailed presentation of PI3K class I isoforms (PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ) including structure and function.
  • Elucidation of PI3K involvement in various signaling cascades and cellular processes.
  • Overview of PI3K inhibitors and their application in immunotherapy.

Conclusions:

  • PI3K dysregulation is implicated in diseases such as APDS, asthma, arthritis, and cancer.
  • Understanding PI3K pathways is crucial for developing targeted therapies and immunotherapies.