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Updated: Aug 25, 2025

Phospho Flow Cytometry with Fluorescent Cell Barcoding for Single Cell Signaling Analysis and Biomarker Discovery
Published on: October 4, 2018
PI3K Isoforms in B Cells
Elissa K Deenick1,2, Julia Bier3,4, Anthony Lau3,4
1Garvan Institute of Medical Research, Darlinghurst, NSW, Australia. e.deenick@garvan.org.au.
Abstract:
Phosphatidylinositol-3-kinases (PI3K) control many aspects of cellular activation and differentiation and play an important role in B cells biology. Three different classes of PI3K have been described, all of which are expressed in B cells. However, it is the class IA PI3Ks, and the p110δ catalytic subunit in particular, which seem to play the most critical role in B cells. Here we discuss the important role that class IA PI3K plays in B cell development, activation and differentiation, as well as examine what is known about the other classes of PI3Ks in B cells.
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