Aquila: a spatial omics database and analysis platform
Yimin Zheng1,2,3,4, Yitian Chen1,2,3,4, Xianting Ding5
1Cancer Centre, University of Macau, Taipa 999078, Macau SAR.
Nucleic Acids Research
|October 16, 2022
Summary
Aquila is a new database for spatial omics data, offering analysis and visualization tools for transcript and protein expression within tissue microenvironments. It provides insights into cellular networks and disease studies.
Area of Science:
- Biotechnology
- Bioinformatics
- Genomics
Background:
- Spatial omics integrates spatial information with molecular data to study tissue microenvironments.
- Existing databases lack comprehensive resources for accessing and analyzing diverse spatial omics datasets.
Purpose of the Study:
- To develop Aquila, a centralized platform for managing and analyzing spatial omics data.
- To provide tools for visualizing and analyzing transcript and protein expression in tissues.
Main Methods:
- Compiled 107 spatial omics datasets covering 30 diseases, including spatial transcriptomics and proteomics.
- Integrated data from 2D and 3D experiments using various technologies.
- Developed visualization tools for cell distribution, marker expression, and co-localization.
Main Results:
- Aquila hosts 15.7 million cells across 6500+ regions of interest.
- The platform supports basic and advanced spatial analyses.
- Users can securely upload their own data for analysis.
Conclusions:
- Aquila offers a comprehensive resource for spatial omics data management and analysis.
- The platform enhances understanding of tissue architecture and molecular interactions.
- Aquila is accessible via a web interface and a desktop application with API support.
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