Genenames.org: the HGNC resources in 2023.

Area of Science:

• Genomics
• Bioinformatics
• Molecular Biology

Background:

• The HUGO Gene Nomenclature Committee (HGNC) is responsible for assigning standardized nomenclature to human genes.
• The HGNC database serves as a comprehensive resource for approved gene symbols and associated information.
• Accurate gene annotation is crucial for genomic research, clinical diagnostics, and understanding gene function.

Purpose of the Study:

• To report on recent updates and improvements to the HGNC database and its public website (www.genenames.org).
• To highlight enhancements in search functionality and new data download features.
• To ensure the HGNC resource remains a valuable and accessible tool for the scientific community.

Main Methods:

• Curating and updating the HGNC database with approved gene symbols and associated data.
• Developing and implementing improvements to the search interface of the www.genenames.org website.
• Introducing new features for downloading curated nomenclature data.

Main Results:

• The HGNC database currently contains over 43,000 approved gene symbols, including those for protein-coding genes, pseudogenes, and non-coding RNA genes.
• The www.genenames.org website now offers enhanced search capabilities for accessing gene information.
• New download functionalities have been implemented, facilitating easier data retrieval for users.

Conclusions:

• The HGNC continues to provide a vital, up-to-date resource for human gene nomenclature.
• Improvements to the HGNC database and website enhance data accessibility and usability for researchers worldwide.
• These updates support advancements in genomics, proteomics, and clinical research by ensuring standardized and easily retrievable gene information.