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Integrated multi-omics approach revealed cellular senescence landscape.

Qiao Song1, Yuli Hou1, Yiyin Zhang2

  • 1Department of Clinical laboratory, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, Beijing 100053, PR China.

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|October 16, 2022
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Cellular senescence, a key factor in aging, involves gene expression changes. This study maps the epigenetic landscape of senescence, identifying potential aging biomarkers NAT1, PBX1, and RRM2.

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Area of Science:

  • Gerontology and molecular biology
  • Epigenetics and cellular aging

Background:

  • Cellular senescence is crucial in aging and age-related diseases, involving altered gene expression and chromatin remodeling.
  • Integrated multi-omics studies of the senescence epigenetic landscape are limited.

Purpose of the Study:

  • To reveal the epigenetic landscape of cellular senescence using integrated multi-omics approaches.
  • To identify key regulatory elements and potential biomarkers for aging and related diseases.

Main Methods:

  • Performed ATAC-seq, RNA-seq, and ChIP-seq on various senescent cell types.
  • Integrated multi-omics data to analyze chromatin accessibility and transcriptional regulation.

Main Results:

  • Mapped the epigenetic landscape of cellular senescence.
  • Identified 34 key genes, including NAT1, PBX1, and RRM2, as potential aging biomarkers.
  • Revealed regulatory elements driving transcriptional changes in senescence.

Conclusions:

  • Provides a comprehensive landscape for studying senescence dynamics and transcriptional regulation.
  • Offers insights into the molecular mechanisms of senescence and identifies potential therapeutic targets.