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Micro/nano devices for integration with human brain organoids.

Hao Nguyen Tran¹, Vini Gautam¹

¹Department of Biomedical Engineering, Faculty of Engineering and Information Technology, The University of Melbourne, Victoria, 3010, Australia.

Biosensors & Bioelectronics

|October 16, 2022

Summary

Micro/nano devices enhance brain organoid research by improving in vitro culture, enabling electrophysiological recordings, and facilitating drug screening for neurological disorders. These technologies are crucial for advancing therapies and understanding brain function.

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Area of Science:

Neuroscience
Biomedical Engineering
Stem Cell Biology

Background:

Brain organoids derived from human-induced pluripotent stem cells offer powerful models for studying neurodevelopment and neurological diseases.
Limitations in brain organoid complexity, functionality, and vascularization hinder their clinical applications.
Micro/nanoscale devices present solutions to overcome these limitations.

Approach:

This review examines novel micro/nano devices integrated with brain organoids.
Focuses on devices for improved in vitro culture, electrophysiological recording, and drug screening.
Highlights applications in chemotherapy, psychoactive drug studies, and vascular network development.

Key Points:

Devices facilitate electrophysiological recordings and drug screening for neurodegenerative disorders.

Keywords:

Brain organoids Drug screening Electrophysiology Micro/nano devices Organoid-on-a-chip Vascularization

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Micro/nano technologies aid in understanding psychoactive drug effects and developing vascular networks.

Integration of devices improves methodologies for in vitro brain organoid culture.

Conclusions:

Micro/nano devices are essential for advancing brain organoid applications in clinical research.
Interdisciplinary collaboration is key to replicating human brain function in vitro.
These technologies offer insights into brain mechanisms and pathways for novel neurotherapeutics.