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Related Experiment Video

Updated: Aug 25, 2025

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

Pain in neuromyelitis optic spectrum disorder.

Huiru Xue¹, Wen Yang¹, Yunfei Zhao¹

¹First Hospital of Shanxi Medical University, Taiyuan, Shanxi province, China.

Multiple Sclerosis and Related Disorders

|October 16, 2022

Summary

Neuromyelitis optica spectrum disorder (NMOSD) pain is common and linked to disease progression. Aquaporin-4 antibody positivity is a key risk factor for NMOSD pain, suggesting targeted treatments.

Keywords:

Aquaporin-4 Neuromyelitis optic spectrum disorders Neuropathic pain Pain Painful tonic spasm

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Area of Science:

Neurology
Immunology
Pain Medicine

Background:

Neuromyelitis optica spectrum disorder (NMOSD) frequently presents with pain, yet research on this symptom is limited.
Understanding NMOSD pain is crucial for improving patient care and disease management.

Purpose of the Study:

To investigate the clinical characteristics of pain in NMOSD patients.
To identify factors associated with NMOSD pain, including antibody status and disease stage.

Main Methods:

Retrospective analysis of medical records from 145 NMOSD patients.
Review of patient data collected between July 2016 and June 2019.

Main Results:

High incidence of pain observed in NMOSD patients.
Pain characteristics correlate with disease localization and stage.
Serum aquaporin-4 antibody (AQP4-ab) positivity identified as an independent risk factor for NMOSD pain.

Conclusions:

Pain presentation varies across different disease stages in NMOSD.
AQP4-ab positivity is a significant predictor of pain in NMOSD.
Hormonal therapies and biological immune agents show potential for managing NMOSD pain.