Modulation of non-coding RNAs by natural compounds as a potential therapeutical approach in oral cancer: A comprehensive review
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Tamires Cunha Almeida1, Isadora Oliveira Ansaloni Pereira2, Edymara Dos Anjos Oliveira2
1Laboratório de Dor e Sinalização, Instituto Butatan, São Paulo, SP, Brazil.
Abstract:
Oral cancer is a disease with high incidence and mortality worldwide, and its treatment still needs to be improved. The search for new therapies using natural products is strongly supported, given the wide chemical range of these compounds. In addition, phytochemicals can exert antitumor activities by several mechanisms of action, including the modulation of non-coding RNAs. Thus, in this review, we discussed the role of non-coding RNAs, including circular RNAs, microRNAs, and long non-coding RNAs, in oral cancer and presented their potential as treatment targets using natural products. Some natural products capable of being used to treat oral cancer have been suggested.
Insights
Natural products offer promising avenues for oral cancer treatment by targeting non-coding RNAs (ncRNAs). This review explores ncRNAs like circular RNAs, microRNAs, and long non-coding RNAs as therapeutic targets for oral cancer.
Area of Science:
- Oncology
- Pharmacology
- Molecular Biology
Background:
- Oral cancer presents a significant global health challenge with high incidence and mortality rates.
- Current oral cancer treatments require improvement, necessitating the exploration of novel therapeutic strategies.
- Natural products, with their diverse chemical structures, are increasingly recognized for their potential in cancer therapy.
Purpose of the Study:
- To review the role of non-coding RNAs (ncRNAs) in oral cancer development and progression.
- To explore the potential of ncRNAs as therapeutic targets for oral cancer.
- To discuss the application of natural products in modulating ncRNAs for oral cancer treatment.
Main Methods:
- Literature review focusing on non-coding RNAs (circular RNAs, microRNAs, long non-coding RNAs) in oral cancer.
- Analysis of the mechanisms by which phytochemicals interact with ncRNAs.
- Identification of natural products with potential anti-oral cancer activity through ncRNA modulation.
Main Results:
- Non-coding RNAs play crucial roles in the molecular mechanisms underlying oral cancer.
- Phytochemicals can modulate the expression and function of ncRNAs involved in oral cancer.
- Several natural products demonstrate potential for oral cancer treatment via ncRNA targeting.
Conclusions:
- Non-coding RNAs represent a promising class of therapeutic targets for oral cancer.
- Natural products offer a viable source of novel agents for oral cancer treatment by targeting ncRNAs.
- Further research into ncRNA-modulating natural products could lead to improved oral cancer therapies.
