Related Experiment Video
Updated: Aug 25, 2025

Isolation and Profiling of MicroRNA-containing Exosomes from Human Bile
Published on: June 13, 2016
The emerging roles of exosome-derived noncoding RNAs in the tumor immune microenvironment and their future
1Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China.
Abstract:
Exosomes are a major subgroup of extracellular vesicles (EVs) generated through the endosomal pathways in the endosomal sorting complex required for the transport in endosomal sorting complex required for transport (ESCRT)-dependent and ESCRT-independent manner. Natural EVs carry various biological materials, including proteins, lipids, nucleic acids and metabolic waste, and act as messengers that mediate multifarious biofunctions. Noncoding RNAs (ncRNAs) are an essential type of EV cargo. Current immunotherapies represented by immune checkpoint blockade have emerged as an important option for tumor treatment. However, our understanding of how cells of the tumor immune microenvironment interact with each other is relatively poor. Thus, we review the current knowledge about the role of exosomal ncRNAs in the tumor immune microenvironment.
Related Concept Videos
Overview of Exosomes
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
lncRNA - Long Non-coding RNAs
MicroRNAs
The Tumor Microenvironment
Tumor Immunotherapy
siRNA - Small Interfering RNAs
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...

