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Effects of Supplemental Dexmedetomidine Anesthesia on Intracranial Aneurysm Patients Undergoing Intracranial

Zhihong Li1, Qingwang Liu2, Junchao Yao1

  • 1Department 5 of Neurosurgery, Cangzhou Central Hospital, Cangzhou, Hebei, China.

World Neurosurgery
|October 16, 2022
PubMed

Insights

Dexmedetomidine (DEX) supplementation improved outcomes for patients undergoing intracranial aneurysm embolization. DEX reduced surgical stress and enhanced cognitive function, leading to better patient recovery.

Area of Science:

  • Neuroscience
  • Anesthesiology
  • Neurosurgery

Background:

  • Intracranial aneurysms (IA) affect 0.4%-3% of the population, causing significant mortality and subarachnoid hemorrhage.
  • Investigating interventions to improve outcomes after IA treatment is crucial.

Purpose of the Study:

  • To evaluate the impact of dexmedetomidine (DEX) as an anesthetic supplement on patient outcomes after intracranial interventional embolization.
  • To assess DEX's effect on surgical stress markers and cognitive function.

Main Methods:

  • A randomized controlled trial involving 96 patients with intracranial aneurysms.
  • Patients received either standard anesthesia or anesthesia supplemented with DEX (0.6 μg/kg).
  • Outcomes measured included Glasgow Outcome Scale, serum stress markers (norepinephrine, cortisol, IL-6, CRP), and cognitive function tests (MMSE, MoCA).

Main Results:

  • DEX supplementation significantly reduced adverse reactions and surgical stress markers.
  • Patients receiving DEX showed attenuated cognitive impairment after extubation.
  • Improved Glasgow Outcome Scale scores were observed in the DEX group.

Conclusions:

  • Dexmedetomidine (DEX) as an anesthetic supplement effectively reduces surgical stress in patients undergoing intracranial interventional embolization.
  • DEX improves postoperative cognitive function and patient recovery.
  • DEX is a beneficial adjunct for managing patients with intracranial aneurysms undergoing embolization.
Abstract

Keywords:
Cognitive impairmentDexmedetomidineIntracranial aneurysmIntracranial interventional embolizationSurgical stress

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