Evaluating Patient-Reported Outcomes in Cushing's Syndrome

Area of Science:

• Endocrinology
• Clinical Research
• Patient-Centered Care

Background:

• Patient-reported outcomes (PROs) are increasingly vital in clinical research and practice.
• PROs capture health status directly from patients, offering unique insights.
• Cushing's syndrome (CS) significantly impacts patients' quality of life.

Purpose of the Study:

• To review patient-reported outcomes (PROs) in Cushing's syndrome (CS).
• To examine PROs concerning signs, symptoms, quality of life, and comorbidities in active CS.
• To explore PROs in CS patients following surgery, radiotherapy, and medical therapy, including long-term outcomes.

Main Methods:

• Literature review focusing on studies reporting patient-reported outcomes in Cushing's syndrome.
• Analysis of PRO data related to active CS and post-treatment phases.
• Exploration of long-term outcomes in remission, persistence, and recurrence of CS.

Main Results:

• PROs provide critical data on the patient experience of CS symptoms and treatment burden.
• Health-related quality of life is a key PRO domain affected by CS and its management.
• Long-term PRO trends in CS remission, persistence, and recurrence require further investigation.

Conclusions:

• Integrating PROs is essential for a comprehensive understanding of Cushing's syndrome.
• PROs enhance the assessment of treatment efficacy and patient well-being in CS.
• Future research should focus on longitudinal PRO data to guide CS management.