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Making a Painless Drain: Proof of Concept.

Anna K Gergen¹, Helen J Madsen¹, Adam J Rocker²

¹Department of Surgery, Division of Cardiothoracic Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO.

Seminars in Thoracic and Cardiovascular Surgery

|October 17, 2022

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This study developed a novel lidocaine-eluting hydrogel coating for chest tubes to reduce postoperative pain. In mice, the coating significantly increased pain tolerance, showing promise for managing pain after cardiothoracic surgery.

Area of Science:

Biomaterials Science
Pain Management
Nanotechnology

Background:

Post-cardiothoracic surgery pain is often severe and linked to chest tubes.
Current pain management strategies may have limitations.

Purpose of the Study:

To develop a cost-effective, easy-to-use lidocaine-eluting hydrogel coating for chest tubes.
To evaluate the efficacy of this coating in reducing pain in a preclinical model.

Main Methods:

A lidocaine-eluting hydrogel was created using gelatin and lidocaine-loaded nanoparticles, crosslinked with glutaraldehyde.
The hydrogel was coated onto silicone discs and implanted in mice.
Pain tolerance was assessed using von Frey filaments on post-procedure days 1 and 3.

Keywords:

Chest tube, Cardiothoracic, Surgery Pain, Pain control, Drain coating

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Main Results:

Lidocaine-eluting discs significantly increased pain tolerance in mice compared to controls on both post-procedure days 1 and 3.
Higher concentrations of lidocaine (80 mg) showed a more pronounced increase in pain tolerance.

Conclusions:

A lidocaine-eluting hydrogel coating for chest tubes was successfully developed and demonstrated efficacy in vivo.
This drug-eluting drain coating concept holds potential for broad application in managing pain associated with various medical drains.