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Updated: Aug 25, 2025

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
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An integrative approach toward identification and analysis of therapeutic targets involved in HPV pathogenesis with a

Amit Kumar Gupta1, Manoj Kumar1,2

  • 1Virology Unit and Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Chandigarh, India.

Cancer Biomarkers : Section a of Disease Markers
|October 17, 2022
PubMed
Abstract

Insights

This study identifies key genes and regulators for targeting human papillomavirus (HPV) oncogenesis, offering potential drug candidates for HPV-mediated carcinomas. Findings aid in developing new biomarkers and therapies for these cancers.

Area of Science:

  • Oncology
  • Virology
  • Genomics
  • Bioinformatics

Background:

  • Persistent high-risk human papillomavirus (HPV) infection causes various carcinomas, including cervical and oropharyngeal.
  • Effective treatments for HPV-associated cancers remain a significant unmet need.

Purpose of the Study:

  • To identify and analyze potential therapeutic targets in HPV oncogenesis.
  • To explore drug repurposing candidates for HPV-driven cancers.

Main Methods:

  • Integrative analysis of 1887 HPV-associated genes from Open Targets Platform and HPVbase.
  • Prioritization of potential targets using STRING, Cytoscape, cytoHubba, and MCODE.
  • Gene ontology, KEGG pathway analysis, TCGA genomic data analysis (CESC, HNSCC), and regulatory network deduction via NetworkAnalyst.

Main Results:

  • Identified 100 key genes and 44 core targets, including transcription factors (TFs) and microRNAs (miRNAs) regulators.
  • Genomic alteration profiling confirmed findings, with TP53, NOTCH1, PIK3CA, EGFR, ERBB2, PTEN, and FN1 frequently mutated.
  • Identified novel regulators like TFs (HINFP, ARID3A) and miRNAs (has-mir-98-5p, has-mir-24-3p).

Conclusions:

  • Potential therapeutic targets and regulators for HPV pathogenesis have been identified.
  • This research facilitates biomarker and drug discovery for HPV-mediated carcinomas.
  • The study provides a foundation for developing novel therapeutic strategies against HPV-driven cancers.
Keywords:
HNSCCHPVsTCGAcervical canceroncogenesisrepurposed drugstherapeutic targets

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