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The High Expression of Adhering and Circulating Integrin Serves as a Diagnostic Marker in Venous Thromboembolism

Fan Yang1, Yanli Song2, Haoming Song3

  • 1Department of Clinical Laboratory, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.

Computational and Mathematical Methods in Medicine
|October 17, 2022
PubMed

Insights

Circulating integrins beta1, beta2, and beta3 show promise as biomarkers for diagnosing venous thromboembolism (VTE). Elevated levels in serum and on cells indicate high diagnostic accuracy for VTE detection.

Area of Science:

  • Biochemistry
  • Hematology
  • Medical Diagnostics

Background:

  • Venous thromboembolism (VTE) poses a significant health risk.
  • Accurate and early diagnosis of VTE is crucial for effective treatment.
  • Integrins play roles in cellular adhesion and immune responses, potentially relevant to thrombosis.

Purpose of the Study:

  • To evaluate the diagnostic utility of circulating integrins beta1, beta2, and beta3 in patients with VTE.
  • To determine the correlation between circulating and adhering integrin levels in VTE.
  • To assess the sensitivity and specificity of these integrins as VTE biomarkers.

Main Methods:

  • Flow cytometry was used to measure adhering integrins beta1, beta2, and beta3 on leukocytes and platelets.
  • Enzyme-linked immunosorbent assay (ELISA) quantified circulating integrins beta1, beta2, and beta3 in serum.
  • A cohort of 474 VTE patients and 306 controls was analyzed.

Main Results:

  • Significantly higher levels of integrins beta1, beta2, and beta3 were observed in the serum and on the surface of leukocytes and platelets in VTE patients.
  • Positive correlations were found between circulating and adhering integrin levels.
  • Circulating integrins demonstrated excellent clinical diagnostic performance for VTE.

Conclusions:

  • Integrin subunit beta (specifically beta1, beta2, and beta3) shows potential as a diagnostic marker for VTE.
  • These circulating integrins offer high sensitivity and specificity for venous thromboembolism diagnosis.
  • Further research may establish integrins as reliable biomarkers for VTE.
Abstract

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