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Follicular lymphoma with cardiac involvement in a 90-year-old patient: A case report
Yi-Xuan Sun1, Jia Wang1, Ji-Heng Zhu1
1Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Insights
This case highlights follicular lymphoma presenting solely as severe heart failure. Cardiac lymphoma diagnosis is challenging due to nonspecific symptoms and poor prognosis.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Oncology
Background:
- Cardiac lymphoma is rare, often secondary to non-Hodgkin's lymphoma.
- Follicular lymphoma is an uncommon cause of cardiac involvement.
Observation:
- A 90-year-old male presented with follicular lymphoma and initially normal cardiac function.
- The patient later developed severe heart failure with left ventricular wall thickening and pericardial effusion.
- Cardiac symptoms were the sole clinical manifestation of the lymphoma.
Findings:
- Follicular lymphoma can present with cardiac involvement leading to heart failure.
- Echocardiography revealed progressive cardiac abnormalities.
- Diagnosis of cardiac lymphoma is often delayed due to nonspecific symptoms.
Implications:
- This case underscores the importance of considering lymphoma in unexplained heart failure.
- Early diagnosis and treatment are crucial for improving outcomes in cardiac lymphoma.
- Further research is needed to improve diagnostic strategies and therapeutic options for cardiac lymphoma.
Background:
The incidence of cardiac lymphoma is low, and it mainly occurs secondary to non-Hodgkin's lymphoma, particularly diffuse large B-cell lymphoma. Here, we report a case of follicular lymphoma with cardiac involvement and severe heart failure as the sole clinical manifestation.
Case Summary:
A 90-year-old male patient was first admitted to our hospital due to an accidentally discovered painless mass in the right lower abdomen. A biopsy of the mass revealed a follicular lymphoma. Positron emission tomography-computed tomography confirmed mild pericardial effusion, and echocardiography showed no structural abnormalities with normal ejection fraction at the time of diagnosis. The patient refused our recommendation of chemotherapy and was re-admitted 4 mo later due to heart failure. A series of subsequent echocardiographic examinations showed thickening of the left ventricular walls and increasing pericardial effusion over the following 2 mo. His heart failure exacerbated despite all symptomatic and supportive treatments. He passed away after an episode of aspiration pneumonia.
Conclusion:
The diagnosis of cardiac lymphoma is difficult as its clinical manifestations are nonspecific, and prognosis is poor.
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