Related Experiment Video
Updated: Aug 25, 2025

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
Published on: September 26, 2016
Contribution of immune cells to bone metastasis pathogenesis
Ningning He1,2,3, Jingting Jiang1,3
1Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Abstract:
Bone metastasis is closely related to the survival rate of cancer patients and reduces their quality of life. The bone marrow microenvironment contains a complex immune cell component with a local microenvironment that is conducive to tumor formation and growth. In this unique immune environment, a variety of immune cells, including T cells, natural killer cells, macrophages, dendritic cells, and myeloid-derived suppressor cells, participate in the process of bone metastasis. In this review, we will introduce the interactions between immune cells and cancer cells in the bone microenvironment, obtain the details of their contributions to the implications of bone metastasis, and discuss immunotherapeutic strategies targeting immune cells in cancer patients with bone metastasis.
Related Concept Videos
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Cells of the Adaptive Immune Response
Differentiation of Common Myeloid Progenitor Cells
The Tumor Microenvironment
Cell-mediated Immune Responses
Regulation of Hematopoietic Stem Cells

