Recent updates on anticancer mechanisms of polyphenols

Area of Science:

• Phytochemistry
• Oncology
• Pharmacology

Background:

• Rising global cancer incidence necessitates novel therapeutic strategies.
• Herbal compounds, particularly polyphenols, are gaining attention for their potential anticancer properties.
• Understanding the molecular mechanisms of these natural compounds is crucial for drug development.

Purpose of the Study:

• To review the molecular mechanisms of action of polyphenols as anticancer agents.
• To evaluate the efficacy and potential applications of natural polyphenols in cancer treatment.
• To identify research gaps and future directions for polyphenol-based cancer therapies.

Main Methods:

• Comprehensive literature search of specialized databases (Web of Science, Pubmed/Medline, Google Scholar, Science Direct).
• Analysis of studies focusing on the molecular mechanisms of polyphenol action against cancer.
• Synthesis of information regarding efficacy, synergistic effects, and safety profiles.

Main Results:

• Natural polyphenols demonstrate efficacy against chemically induced tumor growth.
• Polyphenols exhibit fewer side effects compared to conventional treatments.
• These compounds can enhance the effectiveness of existing therapies like chemotherapy, radiotherapy, and biotherapy by sensitizing cells.

Conclusions:

• Polyphenols represent a promising area for developing novel anticancer treatments.
• Further pharmacological research and clinical trials are essential to validate in vivo efficacy, safety, and toxicity.
• Polyphenols hold potential for integration into current cancer treatment regimens, offering a complementary therapeutic approach.