Healthy Ageing Reflected in Innate and Adaptive Immune Parameters
Adriana Narcisa Munteanu1,2, Mihaela Surcel1, Gheorghița Isvoranu1
1Immunology Laboratory, Victor Babes National Institute of Pathology, Bucharest, 050096, Romania.
Clinical Interventions in Aging
|October 17, 2022
Summary
Healthy aging involves immune system changes, including altered T-cell, B-cell, and neutrophil functions. These immune deregulations are linked to age-related diseases and immune exhaustion over a lifetime.
Area of Science:
- Immunology
- Gerontology
- Cellular Biology
Background:
- Aging is associated with significant alterations in both innate and adaptive immune systems.
- Understanding these immunological changes is crucial for identifying biomarkers of healthy aging and age-related diseases.
Purpose of the Study:
- To quantify the relationship between healthy aging and immune parameters.
- To identify specific innate and adaptive immune indicators associated with age-related diseases.
Main Methods:
- Investigated humoral and cellular immune parameters in 288 healthy donors aged 30-80 years.
- Utilized the SENIEUR protocol for subject selection based on clinical, biochemical, and immunological criteria.
- Performed lymphocyte immunophenotyping and neutrophil oxidative activity assays.
Main Results:
- Observed age-related changes in lymphocyte distribution, including decreased T-CD3+, T-CD8+, and NK cells, with increased T-CD4+, T-CD4+/T-CD8+ ratio, and B cells.
- Found an age-related increase in basal and stimulated neutrophil oxidative activity.
- Noted a decrease in N-Formyl-Methionyl-Leucyl-Phenylalanine stimulated neutrophils with increasing oxidative activity.
Conclusions:
- Healthy aging is characterized by immune system deregulation and exhaustion.
- These immune changes are linked to the development of age-related diseases.
- Specific immune parameters can serve as indicators of healthy aging and disease risk.
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