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Teratologic studies on Alcide Allay gel in rabbits
Journal of Applied Toxicology : JAT
|June 1, 1987
Summary
Alcide Allay gel showed no teratogenic effects in rabbit fetuses. While some fetal growth reduction and skeletal anomalies occurred, they were not statistically significant, indicating the germicidal gel is safe for prenatal exposure.
Area of Science:
- Toxicology
- Reproductive Toxicology
- Dermatology
Background:
- Alcide Allay gel is a germicidal compound.
- Evaluation of topical product safety during pregnancy is crucial.
- Sodium chlorite is the active ingredient.
Purpose of the Study:
- To assess the teratogenic potential of Alcide Allay gel in a rabbit model.
- To determine the safety of topical application during gestation.
Main Methods:
- Pregnant rabbits received topical Allay gel (2 g/kg) or placebo from day 6-18 of gestation.
- Draize scores were used to assess skin irritation.
- Maternal weight gain, fetal weight, fetal length, skeletal, and visceral anomalies were evaluated.
Main Results:
- Moderate to severe erythema observed initially in high-dose group, resolving by day 18.
- Decreased maternal body weight gain in low-dose and placebo groups.
- Significant reduction in fetal weights and lengths across all gel groups.
- Incidence of skeletal and visceral anomalies not statistically different from controls.
Conclusions:
- Alcide Allay gel at 2 g/kg was non-teratogenic to rabbit fetuses.
- Transient skin irritation and effects on fetal growth parameters were noted.
- The study supports the safety of Alcide Allay gel regarding teratogenicity.