Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic and environmental drivers of craniofacial, brain, and pituitary disorders.

Endocrine reviews·2026
Same author

NR3C1 is required for normal somatotrope differentiation and Foxo1 expression in pituitary.

Endocrinology·2026
Same author

Traumatic stress recruits an excitatory orbitofrontal-amygdala pathway to drive maladaptive aggression.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

A case report on atypical chromosomal variations in Turner syndrome.

Molecular cytogenetics·2026
Same author

Diagnostic whole exome sequencing in presumably autosomal recessive inherited retinal dystrophies in an Iranian population.

Scientific reports·2025
Same author

The interplay between FOXO1 and glucocorticoid signaling in promoting the terminal differentiation of somatotropes.

Molecular and cellular endocrinology·2025

Related Experiment Video

Updated: Aug 25, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

2.9K

SARS-COV-2 Notable Mutations and Variants: A Review Article.

Dariush D Farhud1,2,3, Nooshin Mojahed3,4

  • 1School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Iranian Journal of Public Health
|October 17, 2022
PubMed
Summary

The study reviews key mutations and concerning variants of SARS-CoV-2 (COVID-19), analyzing genomic sequences to understand viral evolution and potential impacts on population immunity. Findings highlight structural proteins and non-structural proteins (NSPs) in virus assembly and function.

Keywords:
COVID 19Concerning variantsMutationsSARS-COV-2

More Related Videos

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
18:10

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

Published on: June 16, 2011

29.7K
Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.3K

Related Experiment Videos

Last Updated: Aug 25, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

2.9K
Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
18:10

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

Published on: June 16, 2011

29.7K
Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.3K

Area of Science:

  • Virology
  • Genomics
  • Epidemiology

Background:

  • The global SARS-CoV-2 (COVID-19) pandemic, ongoing since December 2019, is characterized by the emergence of new viral variants due to mutations.
  • These variants, identified in various global locations, present a significant concern due to their potential to alter viral behavior and transmission dynamics.
  • Understanding viral mutations and variants is crucial for managing the epidemic and assessing the development of population immunity.

Purpose of the Study:

  • To review key mutations and concerning variants of SARS-CoV-2 based on the World Health Organization's tracking program.
  • To analyze the genomic sequences of SARS-CoV-2 to understand the roles of its proteins in viral assembly and function.

Main Methods:

  • A comprehensive literature search was conducted in databases from February to March 2022.
  • Studies focusing on SARS-CoV-2 mutations, variants, or both were extracted and screened.
  • A total of 24 studies on mutations, 31 on variants, and 31 on both were included in the review.

Main Results:

  • The review identified and analyzed key mutations and concerning variants of SARS-CoV-2.
  • Genomic sequence analyses were performed to investigate the roles of viral proteins.
  • Structural proteins were identified as critical for virus assembly.

Conclusions:

  • Genomic sequence analysis of SARS-CoV-2 reveals that structural proteins are essential for virus assembly.
  • Non-structural proteins (NSPs) exhibit diverse biochemical properties and potential cellular functions.
  • Continued study of SARS-CoV-2 mutations and variants is imperative for understanding viral evolution and public health implications.