Related Experiment Video
Updated: Aug 25, 2025
Live-Cell Imaging Assays to Study Glioblastoma Brain Tumor Stem Cell Migration and Invasion
Published on: August 29, 2018
Global research trends and hotspots on glioma stem cells
Sirong Song1, Haiyang Wu1, Fanchen Wang1
1Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.
Background:
Glioma stem cells (GSCs) are a sub-population of cancer stem cells with capacity of self-renewal and differentiation. Accumulated evidence has revealed that GSCs were shown to contribute to gliomagenesis, distant metastasis as well as the resistance to radiotherapy and chemotherapy. As a result, GSCs were regarded as a promising therapeutic target in human glioma. The purpose of our study is to identify current state and hotspots of GSCs research by analyzing scientific publications through bibliometric methods.
Methods:
All relevant publications on GSCs during 2003-2021 were extracted from the Science Citation Index Expanded of Web of Science Core Collection (WoSCC), and related information was collected and analyzed using Microsoft Excel 2016, GraphPad Prism 8 and VOSviewer software.
Results:
A total of 4990 papers were included. The United States accounted for the largest number of publications (1852), the second average citations per item (ACI) value (67.54) as well as the highest H-index (157). Cancer Research was the most influential journal in this field. The most contributive institution was League of European Research Universities. RICH JN was the author with the most publications (109) and the highest H-index (59). All studies were clustered into 3 groups: "glioma stem cell properties", "cell biological properties" and "oncology therapy". The keywords "identification", "CD133" and "side population" appeared earlier with the smaller average appearing years (AAY), and the keywords"radiotherapy" and "chemotherapy" had the latest AAY. The analysis of top cited articles showed that "temozolomide", "epithelial-mesenchymal transition", and "immunotherapy" emerged as new focused issues.
Conclusion:
There has been a growing number of researches on GSCs. The United States has always been a leading player in this domain. In general, the research focus has gradually shifted from basic cellular biology to the solutions of clinical concerns. "Temozolomide resistance", "epithelial-mesenchymal transition", and "immunotherapy" should be given more attention in the future.
Insights
Glioma stem cells (GSCs) drive tumor growth and treatment resistance. Research trends show a shift from basic biology to clinical applications, highlighting temozolomide resistance, EMT, and immunotherapy as future focuses.
Area of Science:
- Neuro-oncology
- Cancer Stem Cell Biology
- Bibliometrics
Background:
- Glioma stem cells (GSCs) are key drivers of glioma development, metastasis, and resistance to therapies.
- GSCs represent a critical therapeutic target in human glioma due to their self-renewal and differentiation capabilities.
- Understanding the research landscape of GSCs is crucial for advancing glioma treatment strategies.
Purpose of the Study:
- To conduct a bibliometric analysis of GSC research.
- To identify current trends and emerging hotspots in the field of GSCs.
- To map the evolution of GSC research from 2003 to 2021.
Main Methods:
- Bibliometric analysis of 4990 publications from 2003-2021.
- Data sourced from Web of Science Core Collection (Science Citation Index Expanded).
- Analysis performed using Microsoft Excel, GraphPad Prism, and VOSviewer.
Main Results:
- The United States leads GSC research in publication volume and impact (H-index).
- Key research clusters include GSC properties, cell biology, and oncology therapy.
- Emerging research focuses include temozolomide, epithelial-mesenchymal transition, and immunotherapy.
Conclusions:
- GSC research is rapidly expanding, with the US as a dominant contributor.
- Research focus is shifting from fundamental biology towards clinical applications.
- Future research should prioritize temozolomide resistance, epithelial-mesenchymal transition, and immunotherapy for glioma treatment.
More Related Videos
12:25Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry
Published on: January 7, 2014
09:44Imaging Glioma Initiation In Vivo Through a Polished and Reinforced Thin-skull Cranial Window
Published on: November 20, 2012